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Eicosanoids and inflammation

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      • Which form of COX should preferentially be inhibited to specifically treat inflammation?
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      • What are the 4 symptoms of the inflammatory response?
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      • In which cell type is COX-2 expressed?
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      • What effect do prostaglandins have on blood flow?
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      • COX converts arachidonic acid into [...] and then immediately into [...].
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      • What are the 2 well-characterised forms of COX?
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      • Which thromboxane is PGH2 a precursor for?
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      • In which cell type is COX-1 expressed?
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      • Which enzyme converts arachidonic acid into prostaglandins and thromboxanes?
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      • What effect do prostaglandins have on sensory nerve (pain fibres)?
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      • What are the 2 major pro-inflammatory cytokines which are initially present in the arthritic joint?
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      • Is COX-2 expression induced or constitutive?
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      • Is COX-1 expression induced or constitutive?
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      • Which cell types release prostaglandins (2)?
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      • What does PLA2 convert a phospholipid into?
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      • What are the 4 prostaglandins which PGH2 is a precursor for?
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      • What is the enzyme which converts phospholipids into arachidonic acid?
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      • What is the precursor of eicosanoids?
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      • What effect do prostaglandins have on oedema?
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      • Which enzyme converts arachidonic acid into leukotrienes?
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      • Why does oedema happen in inflammed tissue?
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Tags

Sc14, Sc14l02, Immunology

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