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Most correctly guessed answers

      • A [...]-producing tumour causes acromegaly.
      • GH
      • 100.0%
      • Which disease does a GH-producing tumour cause?
      • Acromegaly
      • 100.0%
      • [...] is the presence of abnormally high levels of plasma PRL.
      • Hyperprolactinaemia
      • 100.0%
      • What is hyperprolactinaemia?
      • Presence of abnormally high levels of plasma PRL
      • 100.0%
      • What 3 symptoms can hyperprolactinaemia cause in males?
      • Gynaecomastia
        Erectile dysfunction
        Infertility
      • 100.0%
      • What 2 symptoms can hyperprolactinaemia cause in females?
      • Galactorrhoea
        Infertility
      • 100.0%
      • Hypersecretion of GH before the fusion of long bone epiphyses results in [...].
      • gigantism
      • 100.0%
      • Hypersecretion of GH after the fusion of long bone epiphyses results in [...].
      • acromegaly
      • 100.0%
      • Hyposecretion of GH before the fusion of long bone epiphyses results in [...].
      • a short stature
      • 100.0%
      • Hyposecretion of GH after the fusion of long bone epiphyses results in [...].
      • adult GH deficiency
      • 100.0%
      • Does a person with acromegaly secrete GH at high levels throughout the day?
      • Yes
      • 100.0%
      • [...] is caused by hyposecretion of ADH.
      • Diabetes insipidus
      • 100.0%
      • [...] is characterized by polydipsia and polyuria with severely diluted urine, with reduction in fluid intake having no effect on urine concentration.
      • Diabetes insipidus
      • 100.0%
      • Does diabetes insipidus present with glucose in the urine?
      • No
      • 100.0%
      • How is diabetes insipidus diagnosed?
      • Water deprivation test
      • 100.0%
      • What is the result of a water deprivation test in diabetes insipidus?
      • No increase in urine osmolality
      • 100.0%
      • What is the difference between central and nephrogenic diabetes insipidus?
      • Central - lack of ADH
        Nephrogenic - lack of renal response to ADH
      • 100.0%
      • What is the mechanism of action of the drugs used to treat hyperprolactinaemia?
      • D2 receptor agonists
      • 80.0%
      • What 4 pharmacological stimuli stimulate GH secretion?
      • Drug-induced hypoglycaemia
        Amino acid infusion
        Small peptide hormones
        Monoamines
      • 80.0%
      • Which 2 drugs are used to treat small stature?
      • Recombinant human GH: Somatropin
        Recombinant human IGF-1: Mecasermin
      • 80.0%
      • Which 2 hormones levels are measured to diagnose gigantism or acromegaly?
      • GH and IGF-1
      • 80.0%
      • How is anterior pituitary function tested?
      • Using a physiological stimulus or inhibitor
      • 80.0%
      • Which drug is used to treat central diabetes insipidus?
      • Desmopressin
      • 80.0%
      • Diabetes insipidus is caused by hyp[...]secretion of [hormone].
      • o, ADH
      • 80.0%
      • Diabetes insipidus present with a serum osmolality of [...] mOsm/L.
      • >290
      • 80.0%
      • Which 2 drugs are used to treat hyperprolactinaemia?
      • Cabergoline
        Bromocriptine
      • 60.0%
      • Which 3 drugs are used to treat acromegaly?
      • D2 receptor agonist: Bromocriptine, Cabergoline
        Somatostatin analogue: Octreotride
      • 60.0%
      • What is the procedure for a GH stimulation test and what is the expected normal result?
      • Fast for 12 hours then give insulin/arginine
        Should cause increase in GH
      • 60.0%
      • What is the procedure for a GH suppression test and what is the expected normal result?
      • Fast for 12 hours then give glucose drink
        Should suppress GH secretion
      • 60.0%
      • Apart from drugs, what 2 methods are used to treat acromegaly?
      • Radiotherapy and surgery
      • 60.0%
      • Hypersecretion of ADH results in [...].
      • SIADH
      • 60.0%
      • Which condition is SIADH associated with?
      • Small cell carcinoma of the lung
      • 60.0%
      • What does SIADH present with (3)?
      • Fluid retention
        Hyponatraemia
        Urine osmolarity > serum osmolarity
      • 60.0%
      • Which 3 drugs are used to treat SIADH?
      • Impairment of ADH signalling: Demeclocycline
        ADH receptor antagonists: Conivaptan (V1a/V2), Tolvaptan (V2)
      • 60.0%
      • Which cell type does GH act on in the epiphyseal plate to stimulate bone growth?
      • Chondrocytes
      • 60.0%
      • Diabetes insipidus presents with a urine specific gravity of [...].
      • <1.006
      • 60.0%
      • Which 3 drugs are used to treat nephrogenic diabetes insipidus?
      • Amiloride
      • 60.0%
      • Which 2 tests are used to test for GH function?
      • GH stimulation test
        GH suppression test
      • 40.0%