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Thyroid physiology 2

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      • Which element is taken up by the thyroid to make T3 and T4?
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      • Which amino acid is used in the thyroid in addition to iodine to make T3 and T4?
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      • How are thyroid epithelial cells organized?
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      • Thyroid epithelial cells secrete [...].
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      • The thyroglobulin which accumulates in thyroid epithelial cells is called [...].
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      • Which element do thyroid follicular cells take up?
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      • In thyroid follicular cells, iodide is [...]ed to iodine.
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      • In thyroid follicular cells, iodide is oxidized to [...].
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      • In thyroid follicular cells, iodine covalently attaches to the [...] amino acids of the [...] protein.
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      • When the thyroid is stimulated by TSH, what do follicular cells do to iodinated thyroglobulin?
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      • Where in the thyroid is iodinated thyroglobulin stored?
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      • Lysosomal degradation of iodinated thyroglobulin in thyroid follicular cells results in the release of the [...] and [...] hormones.
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      • C/parafollicular cells of the thyroid secrete [...].
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      • The colloid in the thyroid represents a store of thyroid hormone which can last how long?
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      • In thyroid follicular cells, the addition of iodine to thyroglobulin yields which 2 iodinated forms of tyrosine?
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      • Which 2 forms of iodinated tyrosine are added to form T3?
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      • Which enzyme oxidizes iodide into iodine in the thyroid?
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      • What are the 3 plasma thyroid hormone-binding proteins?
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      • Once they have entered cells in the periphery, where do thyroid hormones bind?
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      • Where does thyroid hormone-receptor complex bind on DNA?
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      • What effect do high levels of iodine have on thyroid hormone synthesis?
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      • How do high levels of iodine inhibit thyroid hormone synthesis?
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      • How do T3 and T4 enter the cell?
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      • Where in the cell is the T3 and T4 receptor?
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Mbbs2 endocrinology

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