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Most correctly guessed answers

      • What are the 2 high risk genes for breast cancer?
      • BRCA1
        BRCA2
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      • Which type of DNA repair are the BRCA1/2 proteins involved in?
      • Double-stranded break
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      • BRCA1/2 are involved in the repair of which kind of DNA damage?
      • Double-stranded breaks
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      • A BRCA1-/- mutant cell can survive in [...] or [...] tissue but not in other tissues.
      • breast, ovary
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      • What is the frequency of BRCA1/2 mutations in the general population?
      • 1/400
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      • What is the relative penetrance for mutations in BRCA1/2 for breast cancer?
      • High
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      • Do mutations to BRCA1/2 account for a large proportion of breast cancers?
      • No, <5%
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      • Mutations to BRCA1/2 account for [...]% of the familial risk of breast cancer.
      • 20
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      • Females with a BRCA1 mutation have a 80% risk of developing [...] cancer and a 50% risk of [...] cancer.
      • breast, ovarian
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      • Males with a BRCA1 mutation have a 15% risk of developing [...] cancer.
      • prostate
      • -
      • Females with a BRCA2 mutation have a 80% risk of developing [...] cancer, a 30% risk of [...] cancer, and a 3% risk of [...] cancer.
      • breast, ovarian, pancreatic
      • -
      • Males with a BRCA2 mutation have 25% risk of developing [...] cancer, an 8% risk of [...] cancer, and a 3% risk of [...] cancer.
      • prostate, breast, pancreatic
      • -
      • Females with a BRCA[...] mutation have a 80% risk of developing breast cancer, a 30% risk of ovarian cancer, and a 3% risk of pancreatic cancer.
      • 2
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      • Males with a BRCA[...] mutation have 25% risk of developing prostate cancer, an 8% risk of breast cancer, and a 3% risk of pancreatic cancer.
      • 2
      • -
      • Males with a BRCA[...] mutation have a 15% risk of developing prostate cancer.
      • 1
      • -
      • Females with a BRCA[...] mutation have a 80% risk of developing breast cancer and a 50% risk of ovarian cancer.
      • 1
      • -