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Myasthenia gravis and LEMS

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      • [...] is an autoimmune disease most commonly caused by the destruction of nicotinic cholinergic receptors post-synaptically at the neuromuscular junction.
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      • What is the major symptom of myasthenia gravis?
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      • In 15% of cases of myasthenia gravis, symptoms are limited to which area of the body?
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      • A [...] occurs when myasthenia gravis reaches the respiratory muscles.
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      • What is the most common condition that electromyography is used to diagnose?
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      • Which disease is associated with fatiguability following repetitive stimulation on single fibre EMG?
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      • Which 3 groups of muscles are most commonly affect by myasthenia gravis?
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      • Hyperplasia of the [...] is found in 70% of cases of myasthenia gravis.
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      • Hyperplasia of the thymus is found in [...]% of cases of myasthenia gravis.
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      • A thymoma is found in [...]% of cases of myasthenia gravis.
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      • A [...] is found in 10% of cases of myasthenia gravis.
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      • Myasthenic patients with thymomas sometimes have Ab against [...] or thyroid tissue.
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      • What are the 2 groups of myasthenic patients by age/sex?
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      • Acute, severely fluctuating, generalized myasthenia gravis more commonly affect [...] [...].
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      • Oculobulbar myasthenia gravis more commonly affects [...] [...].
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      • What is the presenting complaint in 50% of cases of myasthenia gravis?
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      • [...] occurs when a myasthenic is asked to look down for a period, then up.
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      • What are 2 clinical tests for myasthenia gravis?
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      • Does myasthenia gravis present with muscle wasting?
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      • Does myasthenia gravis present with sensory deficits?
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      • Does myasthenia gravis present with abnormal reflexes?
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      • What is the differential diagnosis for a young woman presenting with complex ophthalmoplegia (3)?
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      • [...] is used to diagnose myasthenia gravis. 
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      • When a myasthenic is given Edrophonium, symptoms improve within [...] and for up to [...].
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      • How is Edrophonium administered to diagnose myasthenia gravis?
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      • Which drug is co-administered with Edrophonium to diagnose myasthenia gravis and why?
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      • 85% of patients with generalized myasthenia gravis have the anti-[...] Ab.
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      • [...]% of patients with generalized myasthenia gravis have the anti-AChR Ab.
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      • [...]% of patients with ocular myasthenia gravis have the anti-AChR Ab.
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      • 50% of patients with ocular myasthenia gravis have the anti-[...] Ab.
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      • [...]% of myasthenic patients who are anti-AChR seronegative have the anti-MUSK Ab.
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      • 50% of myasthenic patients who are anti-[...] seronegative have the anti-MUSK Ab.
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      • 50% of myasthenic patients who are anti-AChR seronegative have the anti-[...] Ab.
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      • What are the 2 auto-Ab which are diagnostic of myasthenia gravis?
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      • Which imaging must be done in a patient with suspected myasthenia gravis?
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      • Myasthenic patients with thymomas sometimes have Ab against striated muscle or [...].
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      • What is the time of onset of Pyridostigmine?
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      • What is the duration of action of Pyridostigmine?
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      • What is the most common acetylcholinesterase inhibitor used to treat myasthenia gravis?
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      • Which surgery should be considered for myasthenic patients?
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      • Are acetylcholinesterase inhibitors disease-modifying drugs for myasthenia gravis?
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      • Can immunosuppressants be used to treat myasthenia gravis?
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      • How is myasthenia gravis treated (3)?
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      • [...] is a rare condition associated with Ab against presynaptic voltage-gated Ca2+ channels at the NMJ.
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      • Lambert-Eaton myasthenic syndrome is a rare condition associated with Ab against [...] at the NMJ.
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      • What is the classical presentation of LEMS in terms of motor function?
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      • LEMS is associated with [...].
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      • Are the ocular muscles typically involved in LEMS?
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      • Are the cranial muscles typically involved in LEMS?
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      • How is LEMS different from myasthenia gravis in terms of fatigability?
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      • Does LEMS present with abnormal reflexes?
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      • Is there autonomic involvement in LEMS?
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      • In which subtype of LEMS is autonomic involvement common?
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      • [...] is an abnormal twitch of the eyelid.
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      • Ingestion of [toxin...] can mimic myasthenia gravis.
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      • Ingestion of botulinum from Clostridium botulinum can mimic [...].
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Mbbs3 neuro

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