Results and stats for "Anti-inflammatory drugs"
NSAID: non-steroidal anti-inflammatory drug
DMARD: disease-modifying anti-rheumatoid drug
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Most correctly guessed answers
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- What is the mechanism of action of NSAIDs?
- COX inhibitor
- 55.6%
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- Which form of COX has selective inhibitors?
- COX-2
- 55.6%
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- Are DMARDs slow- or fast-acting?
- Slow-acting
- 55.6%
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- What is the mechanism of action of DMARDs?
- Large range
- 55.6%
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- If NSAIDs aren't sufficient to manage rheumatoid arthritis, which drugs are tried next?
- DMARD
- 50.0%
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- Do DMARDs have serious side effects?
- Yes
- 50.0%
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- What is the aetiology of rheumatoid arthritis?
- Unknown
- 44.4%
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- What is the aim of treatment for rheumatoid arthritis?
- Symptom relief, conservation of joints, and suppression of active disease
- 44.4%
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- If the initial treatment of rheumatoid arthritis with education, physiotherapy, and rest don't work, which drugs are tried next?
- NSAIDs
- 44.4%
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- If DMARD aren't sufficient to manage rheumatoid arthritis, what drugs are tried next (3)?
- Biologics, steroids, cytotoxics
- 44.4%
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- What are the 3 main effects of NSAIDs?
- Analgesic, anti-pyretic, anti-inflammatory
- 44.4%
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- Which 2 eicosanoid types do NSAIDs inhibit the production of?
- Prostaglandins and thromboxanes
- 44.4%
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- What is a dangerous side effect of non-selective COX inhibitors?
- Gastro-intestinal bleeding (gut and kidney)
- 44.4%
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- What dangerous side effect caused selective COX-2 inhibitors to be banned?
- Doubles risk of heart attack and sudden death
- 44.4%
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- How can side effects of steroids be minimised?
- Give locally instead of systemically
- 44.4%
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- What are the first steps to treating rheumatoid arthritis (4)?
- Patient education (exercise and diet for weight loss), physiotherapy, rest/exercise, OTC painkillers
- 33.3%
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- Which type of eicosanoid do NSAIDs not inhibit the production of?
- Leukotrienes
- 33.3%
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- In which 2 ways do corticosteroids and glucocorticoids inhibit the immune response?
- Inhibit T lymphocyte proliferation and induce apoptosis in immune cells
- 33.3%
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- Apart from physiotherapy, which non-systemic treatments can be used to treat rheumatoid arthritis (3)?
- Topical creams, intra-articular steroids, surgery
- 27.8%
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- In which 4 ways do corticosteroids and glucocorticoids have anti-inflammatory activity?
- Inhibit arachidonic acid release, inhibit cytokines, down-regulate adhesion molecules, inhibit COX and iNOS
- 27.8%
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- Do selective COX-2 or non-selective COX inhibitors cause more fatalities due to severe side effects?
- Similar numbers
- 22.2%
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