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Most correctly guessed answers

      • What are the 4 symptoms of the inflammatory response?
      • Heat, pain, swelling, redness
      • 46.7%
      • What does PLA2 convert a phospholipid into?
      • Arachidonic acid
      • 46.7%
      • Which enzyme converts arachidonic acid into prostaglandins and thromboxanes?
      • COX
      • 46.7%
      • Which thromboxane is PGH2 a precursor for?
      • TxA2
      • 46.7%
      • What effect do prostaglandins have on sensory nerve (pain fibres)?
      • Sensitisation
      • 46.7%
      • What effect do prostaglandins have on oedema?
      • Increase
      • 46.7%
      • What are the 2 well-characterised forms of COX?
      • COX-1 and -2
      • 46.7%
      • In which cell type is COX-2 expressed?
      • Inflammatory cells
      • 46.7%
      • Which form of COX should preferentially be inhibited to specifically treat inflammation?
      • COX-2
      • 46.7%
      • Why does oedema happen in inflammed tissue?
      • Increased filtration in the venules
      • 40.0%
      • What is the precursor of eicosanoids?
      • Arachidonic acid
      • 40.0%
      • What is the enzyme which converts phospholipids into arachidonic acid?
      • Phospholipase A2 (PLA2)
      • 40.0%
      • Which enzyme converts arachidonic acid into leukotrienes?
      • Lipoxygenase
      • 40.0%
      • What are the 4 prostaglandins which PGH2 is a precursor for?
      • PGI2 (prostacyclin), PGD2, PGE2, PGFalpha
      • 40.0%
      • What effect do prostaglandins have on blood flow?
      • Increase
      • 40.0%
      • In which cell type is COX-1 expressed?
      • Ubiquitous
      • 40.0%
      • Is COX-1 expression induced or constitutive?
      • Constitutive
      • 40.0%
      • Is COX-2 expression induced or constitutive?
      • Induced by inflammatory stimuli
      • 40.0%
      • COX converts arachidonic acid into [...] and then immediately into [...].
      • PGG2, PGH2
      • 33.3%
      • What are the 2 major pro-inflammatory cytokines which are initially present in the arthritic joint?
      • TNF-alpha and IL-1
      • 26.7%
      • Which cell types release prostaglandins (2)?
      • Inflammatory cells and endothelial cells
      • 26.7%